Kodein er et opioid som finnes naturlig i opiumsplanten. Fordi Paralgin forte inneholder kodein, er det et sterkere medikament en Paracet og tilsvarende legemidler. I medisinsk sammenheng brukes kodein til behandling av tørrhoste i tillegg til smertebehandling.
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Maternally poisonous doses which were about seven periods the most recommended human dose of 360 mg/day, ended up connected with proof of bone resorption and incomplete bone ossification. Codeine didn't demonstrate evidence of embrytoxicity or fetotoxicity while in the rabbit design at doses approximately 2 moments the maximum suggested human dose of 360 mg/working day dependant on a overall body floor area comparison . Nonteratogenic outcomes
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The relief of pain (analgesia) is a Most important objective for maximizing the Standard of living of patients and for escalating the flexibility of individuals to have interaction in daily things to do. Codeine, an opioid analgesic, was originally permitted within the US in 1950 which is a drug utilized to minimize pain by expanding the threshold for suffering with out impairing consciousness or altering other sensory features. Opiates for instance codeine are derived with the poppy plant, Papaver somniferum (Papaveraceae).
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Codeine is an opioid analgesic applied to treat moderate to serious ache when using an opioid is indicated.
Overdose and liver toxicity Acetaminophen overdose could possibly be manifested by renal tubular necrosis, hypoglycemic coma, and thrombocytopenia. In some cases, liver necrosis can happen along with liver failure.
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Pasienter med stort alkoholforbruk/relegmessig alkoholinntak bør informeres om den økte risikoen for leversakde og opfordres til måtehold med alkohol.
GraviditetEn stor mengde data fra gravide indikerer hverken misdannelser eller toksisitet av paracetamol hos foster/nyfødt barn. Epidemiologiske studier på nevronal utvikling hos barn eksponert for paracetamol in utero viser ikke entydige resultater. Ved langvarig behandling med get more info kodein hos mor less than graviditet er det sett neonatal abstinens. Det er sett neonatal respirasjonsdepresjon ved bruk av kodein ved fødsler. Paralgin forte/Paralgin important skal bare brukes beneath graviditet hvis fordel oppveier mulig risiko, og da med lavest mulig effektiv dose i kortest mulig tid og lavest mulig frekvens.
Blanding med andre dempende rusmidler/legemidler som alkohol eller benzodiazepiner forsterker virkingen av både kodein og stoffet du blander med. Blanding med andre dempende stoffer øker også faren for skadelige effekter som kvalme og brekninger, pustevansker og i verste fall overdose.
Distribusjonsvolumet vil være ca. 5 liter hos et voksent menneske for et legemiddel som hovedsakelig befinner seg i plasma.